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Hypo-Selenium (Selenium)
Dosaage
200 mcg.Size 90 tablets
Ingredient
Selenium 200 mcg (Yeast free selenium organically bound in Kelp)
Direction
Adults take 1 tablet daily or as directed by physician
About Selenium
An Essential Mineral, Selenium is a natural antioxidant which delays the oxidation of polyunsaturated fatty acids and preserves the elasticity of tissue. Selenium is required for the production of certain prostaglandins which decrease platelet aggregation. In synergy with vitamin E, selenium promotes normal growth and fertility, and improves the function of certain energy producing cells. Both selenium and vitamin E independently stimulate the formation of antibodies, proteins that act as the body's defense system. Selenium protects normal cell function by supporting the body's natural defenses and scavenging harmful free radicals. Daily intake of Selenium greatly reduce occurrence of some cancers.
Scientific Studies
The most important blind study on selenium and cancer was a double-blind intervention trial conducted by researchers at the University of Arizona Cancer Center.10
When all the results were tabulated, it became clear that the selenium-treated group developed almost 66% fewer prostate cancers, 50% fewer colorectal cancers, and about 40% fewer lung cancers as compared with the placebo group. (All these results were statistically significant.) Selenium-treated subjects also experienced a statistically significant (17%) decrease in overall mortality, a greater than 50% decrease in lung cancer deaths, and nearly a 50% decrease in total cancer deaths.A large-scale Chinese studies showing that giving selenium supplements to people who live in selenium-deficient areas reduces the incidence of cancer.11
Another study examined whether selenium supplements could stop the spread (metastasis) of cancer in mice. In this study, a modest dosage of supplemental selenium reduced metastasis by 57%.12 Even more significant was the decrease in the number of tumors that had spread to the lungs.
References
1. Gallegos A, Berggren M, Gasdaska JR, et al. Mechanisms of the regulation of thioredoxin reductase activity in cancer cells by the chemopreventive agent selenium. Cancer Res. 1997;57:4965-4970.
2. Harrison PR, Lanfear J, Wu L, et al. Chemopreventive and growth inhibitory effects of selenium. Biomed Environ Sci. 1997;10:235-245.
3. Institute of Medicine. Dietary Reference Intakes for Vitamin C, Vitamin E, Selenium and Carotenoids. National Academy Press, 2000.
4. Clark LC, Combs GF Jr, Turnbull BW, et al. Effects of selenium supplementation for cancer prevention in patients with carcinoma of the skin. A randomized controlled trial. Nutritional Prevention of Cancer Study Group. JAMA. 1996;276:1957-1963.
5. Schrauzer GN, Sacher J. Selenium in the maintenance and therapy of HIV-infected patients. Chem Biol Interact. 1994;91:199-205.
6. Constans J, Pellegrin JL, Sergeant C, et al. Serum selenium predicts outcome in HIV infection. [letter]. J Acquir Immune Defic Syndr Hum Retrovirol. 1995;10:392.
7. Baum MK, Shor-Posner G, Lai S, et al. High risk of HIV-related mortality is associated with selenium deficiency. J Acquir Immune Defic Syndr Hum Retrovirol. 1997;15:370-374.
8. Campa A, Shor-Posner G, Indacochea F, et al. Mortality risk in selenium-deficient HIV-positive children. J Acquir Immune Defic Syndr Hum Retrovirol. 1999;20:508-513.
9. Dworkin BM. Selenium deficiency in HIV infection and the acquired immunodeficiency syndrome (AIDS). Chem Biol Interact. 1994;91:181-186.
10. Clark LC, Combs GF Jr, Turnbull BW, et al. Effects of selenium supplementation for cancer prevention in patients with carcinoma of the skin. A randomized controlled trial. Nutritional Prevention of Cancer Study Group. JAMA. 1996;276:1957-1963.
11. Yu SY, Zhu YJ, Li WG. Protective role of selenium against hepatitis B virus and primary liver cancer in Qidong. Biol Trace Elem Res. 1997;56:117-124.
12. Yan L, Yee JA, McGuire MH, et al. Effect of dietary supplementation of selenite on pulmonary metastasis of melanoma cells in mice. Nutr Cancer. 1997;28:165-169.
Caution
Selenium dosages above 850 mcg daily are known to cause selenium toxicity. Signs of selenium toxicity include depression, nervousness, emotional instability, nausea, vomiting, and in some cases loss of hair and fingernails.
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This is a statement of nutritional support. This statement has not been evaluated by the FDA. This product is not intended to medically diagnose, treat, cure, or prevent any disease. Always consult your health care provider before using any supplement.