Marine Lipid Concentrate by ITI (Integrative Therapeutics, Inc)

(Omega-3 Fatty Acids, Evidence-Based)

Targeted support for cardiovascular, neurological, musculoskeletal, and immune health

Dosage 1gram Size 90 Softgels

Direction Adults take 1 softgel with each meal or as directed by your healthcare practitioner.

Ingredient per serving size of 1 Softgel

Calories 15 Calories from fat 10

Fish Oil Concentrate 1.2 g

Polyunsaturated fat 1 g

EPA (eicosapentaenoic acid) 360 mg 277%

DHA (docosahexaenoic acid) 240 mg 185%

Gelatin, vegetable glycerin, water, d-alpha tocopherol (antioxidant), and soybean oil.

If pregnant, nursing, or taking prescription drugs, consult your healthcare practitioner prior to use.

Marine Lipid Concentrate offers concentrated amounts of the omega-3 essential fatty acids, EPA and DHA, in a softgel capsule. Marine source polyunsaturated oils continue to be the subject of international research and have been shown to support cardiovascular, neurological, musculoskeletal and immune health.

Omega-3 fatty acid EPA is the direct precursor for the anti-inflammatory prostaglandins E1 and E3, whereas DHA is of primary importance for the structural integrity of neuronal membranes. DHA is essential for brain and visual development and is vital throughout pregnancy to support fetal brain growth and formation of the retina and visual cortex. Low levels of DHA may adversely influence behavior and mental performance and have been correlated with changes in disposition, memory loss, and visual and other neurological conditions.

These omega-3 fatty acids keep blood triglycerides in check (high triglycerides are generally linked with increased risk of heart disease) and may inhibit the progression of atherosclerosis. Fish oil appears to modestly raise the levels of HDL ("good") cholesterol. Additionally, it may help the heart by "thinning" the blood and by reducing blood levels of homocysteine. Blood clots play a major role in heart attacks, and homocysteine is an amino acid that appears to raise the risk of heart disease.

The reasons for the dramatic benefits with respect to heart disease may he related to the ability of fish oil to reduce inflammation, a process intricately involved in the progression of atherosclerosis.1 Researchers believe that the body's inflammatory response to certain factors, along with a fatty diet, can increase the amount of plaque in the arteries, leading to atherosclerosis. Studies indicate that EPA and DHA can act as precursors for the anti-inflammatory prostaglandins E1 and E3, and decrease the formation of pro-inflammatory prostaglandin E2 and thromboxane A2. Omega- 3 fatty acids may be able to modify sodium channels by binding to the channel proteins. This could then prevent ischemia-induced ventricular fibrillation and sudden cardiac death.

References

1. Von Schacky C, Angerer P, Kothny W, et al. The effect of dietary omega-3 fatty acids on coronary atherosclerosis. A randomized, double-blind, placebo-controlled trial. Ann Intern Med 1999;130:554-62.

2. Mate J, Castanos R, Garcia-Samaniego J, Pajares JM. Does dietary fish oil maintain the remission of Crohn's disease: a case control study. Gastroenterology 1991;100:A228 [abstract].

3. Kremer JM, Lawrence DA, Petrillow GF, et al. Effects of high­dose fish oil on rheumatoid arthritis after stopping nonsteroidal antiinflammatory drugs. Arthritis Rheum 1995;38:1107-14.

4. Donadio JV Jr, Bergstrahl EJ, Offord KP, et al. A controlled trial of fish oil in IgA nephropathy. N Engl J Med 1994;331:1194-9.

5. Peck LW. Essential fatty acid deficiency in renal failure: can supplements really help? J Am Dietet Assoc 1997;97:5150-3.

6. Donadio JV Jr, Grande JP, Bergstralh EJ, et al. The long-term outcome of patients with IgA nephropathy treated with fish oil in a controlled trial. Mayo Nephrology Collaborative Group. J Am Soc Nephrol 1999;10:1772-7.

7. Shahar E, Folsom AR, Melnick SL, et al. Dietary n-3 polyunsaturated fatty acids and smoking-related chronic obstructive pulmonary disease. Atherosclerosis Risk in Communities Study Investigators. N Engl J Med 1994;331:228-33.

8. Maes M, Christophe A, Bosmans E, et al. In humans, serum polyunsaturated fatty acid levels predict the response of proinflammatory cytokines to psychological stress. Biol Psychiatry 2000;47:910-20.

9. DiGiacoma RA, Kremer JM, Shah DM. Fish-oil dietary supplementation in patients with Raynaud's phenomenon: a double-blind, controlled, prospective study. Am J Med 1989;86:158-64.

10. Laugharne JDE, Mellor JE, Peet M. Fatty acids and schizophrenia.Lipids 1996;31:S163-5.

11. Alexander JW. Immunonutrition: the role of omega-3 fatty acids.Nutr 1998;14:627-33.

12. Braden LM, Carroll KK. Dietary polyunsaturated fat in relation to mammary carcinogenesis in rats. Lipids 1986;21(4):285.

13. O'Connor TP, Roebuck BD, Peterson F, et al. Effect of dietary intake of fish oil and fish protein on the development of L-azaserine-induced preneoplastic lesions in the rat pancreas. J Natl Cancer Inst 1985;75:959-62.

14. Gonzalez MJ. Fish oil, lipid peroxidation and mammary tumor growth. J Am Coll Nutr 1995;14:325.

15. Zhu ZR, Mannisto JAS, Pietinene P, et al. Fatty acid composition of breast adipose tissue in breast cancer patients and patients with benign breast disease. Nutr Cancer 1995;24:151-60.

16. Nair SSD, Leitch JW, Falconer J, Garg ML. Prevention of cardiac arrhythmia by dietary (n-3) polyunsaturated fatty acids and their mechanism of action. J Nutr 1997;127:383-93.

This is a statement of nutritional support. This statement has not been evaluated by the FDA. This product is not intended to medically diagnose, treat, cure, or prevent any disease. Always consult your health care provider before using any supplement.