On any given day 56,000 new LIPITOR prescriptions are written and 386,372 LIPITOR tablets are distributed per hour.

Despite their popularity, there are many potential problems with use of Statin especially on a long term basis such as

1. CoQ10 deficiency
2. Liver problems and elevated liver enzymes
3. Polyneuropathy (Chances of nerve damage were 26 times higher than the normal population)
4. Rhabdomyolysis (Muscle pain and weakness)
5. Brain and central nervous system (Some patients suffered measurable decline in cognition after prolonged use)
6. The risk of cancer and heart failure increases with long term use of statins.
7. Cost up to $228/month

 Note: Red Yeast Rice has the same side effect profile as the Statins. Therefore, Dr. Tsang does not recommend Red Yeast Rice.

Sytrinol is a unique and powerful ingredient for maintaining cholesterol and triglycerides. It is a patented combination of citrus PMFs (polymethoxylated flavones) and alpha, delta and gamma tocotrienols derived from palm fruit (U.S. patents #6,251,400, and #6,239,114). Clinical studies in both animals and humans support Sytrinol's role in reducing total cholesterol and LDL-cholesterol as well as triglycerides.

Its action includes

Sytrinol provides a patented and well-researched combination of flavonoids derived from the peel of tangerines and tocotrienols derived from palm. Within the peel of certain fruits, compounds belonging to a class of flavonoids called polymethoxylated flavones (PMFs) can be found. The primary PMFs present in Sytrinol are nobiletin and tangeretin. Science on PMFs dates back to the 1960s and covers both their antioxidant as well as their anti-inflammatory actions. Specifically, with respect to cholesterol metabolism, PMFs have been shown to decrease apolipoprotein B, the structural protein needed for the synthesis of LDL-cholesterol. Nobiletin and tangeretin have also been shown to decrease diacylglycerol acetyt transferase, an enzyme in the liver involved in the synthesis of triglycerides. In addition to PMFs, Sytrinol contains tocotrienols derived from palm. Tocotrienols is a group of compounds belonging to the vitamin E family, have also been studied over the years for their ability to act as antioxidants and to help support cardiovascular health. Tocotrienols have been shown to inhibit HMG-CoA reductas, the hepatic enzyme responsible for the rate limiting step in the synthesis of cholesterol. Consequently, the combined action of the PMFs and tocotrienols contained in Sytrinot results in a powerful synergistic action to support cardiovascular health. Studies have shown that subjects with carotid atherosclerosis who consumed tocotrienols for 2 years had a reduction in amount of cholesterol-laden plaque in their carotid arteries compared with those who received a placebo.

Sytrinol - 3 human clincal studies

In the first study, 10 subjects having an average total cholesterol >230 mg/dl, [DL-cholesterol > 155 mg/dl and total triglycerides of between 100 and 307 mg/dl received 300 mg of Sytrinol for 4 weeks. Compared with baseline values, total cholesterol decreased by 24%, LDL-cholesterol decreased by 19% and triglycerides dropped by 24%. These results were confirmed in a second study also involving 10 hypercholesterolemic subjects in whom similar reductions in lipid parameters were observed. A 21% reduction in apolipoprotein B levels was also observed in this study, supporting the notion that polymethoxylated flavones inhibit apo B secretion.

Third studies is a double-blind, placebo-controlled, randomized, 3-phase, cross-over study involving 120 hypercholesterolemic subjects. During phase one subjects received either 300 mg/day of Sytrinol or a placebo for 12 weeks. Blood was drawn at baseline, 4, 8 and 12 weeks. The second phase of the study consisted of a 4 week washout period, followed by phase 3 in which the subjects were crossed over, so that those that received the placebo in phase 1 would then receive the active treatment. After 12 weeks, compared with baseline values, subjects receiving Sytrinol experienced statistically significant average reductions for total cholesterol, LDL-cholesterol and triglycerides of 27, 25, and 30%, respectively. LDL/HDL ratio was significantly improved. No significant changes were reported in the placebo group. HDL-cholesterol was not significantly altered in either group.

Blood cholesterol is derived from the diet and synthesized in the liver. Plant sterols are naturally occurring plant compounds that have structures similar to, yet slightly different from cholesterol. Typical plant sterols are compounds such as Beta-sitosterol, campesterol, and stigmasterol and can be found in vegetables, fruits. legumes, nuts, grains and certain oils. Research has shown that these compounds compete with the absorption of dietary cholesterol as well as inhibit the reabsorption of endogenous cholesterol in the gastrointestinal tract. Supplementation with plant sterols can significantly lower cholesterol levels and have been shown to work synergistically with other therapies for lowering cholesterol. Numerous foods including orange juice, rice drink, and margarine now incorporate plant sterols, or sterol esters. lncreasingly, dietary supplements are now incorporating plant sterols and using the health claim that has been allowed for products containing at least 800 mg of plant sterols daily.

Recent science has been focusing on the cardioprotective aspects of pomegranate. In addition to the fact that the fruit tastes delicious and is fun to eat, these brightly colored fruits contains numerous cornpounds known for their antioxidant capabilities, induding anthocyanidins, catechins, tannins, and gallic and ellagic acids. Research has shown that supplementation with pomegranate juice can decrease macrophage lipid accumulation, cellular cholesterol accumulation as well as reduce the development of atherosclerosis. in mice. Recently, research in humans has confirmed a beneficial effect of consuming pomegranate juice on parameters such as LDL oxidation, blood pressure, and blood vessel health. Pomegranate juice consumption by patents with carotid artery stenosis reduces cornmon carotid artery intima-media thickness, blood pressure and LDL oxidation. A report out of Israel earlier this year showed that after 1 year of pomegranate juice consumption, subjects with severe atherosclerosis experienced up to a 30% reduction in intima-media thickness compared with an increase in intima-thickness of 9% in the placebo group.

References:

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Dr. Tsang wishes to share his knowledge & Opinion with the public regarding the importance of " Nutritional Supplements ". This is for your information only. Drugs have powerful effects on the body, so please don't abruptly stop taking any prescription medication. Always consult your physician or health care provider before you use any nutritional supplement or switch from drugs to natural health products.