Dr. HingHau Tsang's Crusade on Nutrition

 

Newsletter #71 --- Heart protective nutrient - L-carnitine

 

L-carnitine is an amino acid, and it can be a wonderful supplement.

L-carnitine is needed to release energy from fat. It transports fatty acids into mitochondria, the powerhouses of cells.

Dairy and red meat contain the greatest amounts of carnitine. Therefore, vegetarians and people who have a limited intake of meat and dairy products tend to have lower L-carnitine intakes. Carnitine deficiencies are rare, because the body produces carnitine relatively easily. L-carnitine is made in the body from the amino acids, lysine and methionine. Rare genetic diseases can cause a carnitine deficiency. Carnitine deficiencies are occasionally associated with other diseases, such as diabetes and cirrhosis. Among people with diabetes, carnitine deficiency is more likely to be found in persons experiencing complications of diabetes (such as retinopathy, hyperlipidemia, or neuropathy), suggesting that carnitine deficiency may play a role in the development of these complications. A carnitine deficiency can also result from oxygen deprivation which can occur in some heart conditions.

L-carnitine has been used in the following conditions

L-carnitine's actions appear to be particularly important in the heart. In Italy, L-carnitine is prescribed for heart failure, heart arrhythmias, angina, and lack of oxygen to the heart.

In a preliminary study patients with diabetes and high blood pressure were given 4 grams of L-carnitine per day. After 45 weeks, irregular heartbeat and abnormal heart functioning decreased significantly compared to nonsupplemented patients. In one double-blind trial, using 500 mg propionyl-L-carnitine (PC) per day led to a 26% increase in exercise capacity after six months. In other research, patients with congestive heart failure given 1.5 grams PC daily for 15 days had a 21% increase in exercise tolerance and a 45% increase in oxygen consumption.

Research shows that people who supplement with L-carnitine while engaging in an exercise regimen are less likely to experience muscle soreness.

L-carnitine has been given to people with chronic lung disease in trials investigating how the body responds to exercise. In these double-blind reports, 2 grams of L-carnitine taken twice per day for two to four weeks led to positive changes in lung function and metabolism during exercise.

Beta thalassemia major is an inherited, fatal form of anemia commonly seen in people of Mediterranean descent. People with beta thalassemia major invariably require blood transfusions, which can eventually result in iron overload. L-carnitine stabilizes red blood cells and supplementation may decrease the need for blood transfusions. In a preliminary study, children with beta thalassemia major who took 100 mg of L-carnitine per 2.2 pounds of body weight per day for three months, had a significantly decreased need for blood transfusions.

It is true that L-carnitine aids in muscle metabolism and is protective of heart muscle.

For therapeutic use, typical amounts are 1-3 grams per day.

 

Lastly, Heart protective supplements should include the followings:

 

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References:

1. Giovannini M, Agostoni C, Salari PC. Is carnitine essential in children? J Int Med Res 1991;19:88-102.

2. Digiesi V, Palchetti R, Cantini F. The benefits of L-carnitine in essential arterial hypertension. Minerva Med 1989;80:227-31.

3. Mancini M, Rengo F, Lingetti M, et al. Controlled study on the therapeutic efficacy of propionyl-L-carnitine in patients with congestive heart failure. Arzneimittelforschung 1992;42:1101-4.

4. Anand I, Chandrashenkhan Y, De Giuli F, et al. Acute and chronic effect of propionyl-L-carnitine on the hemodynamics, exercise capacity and hormones of patients with congestive heart failure. Cardiovasc Drugs Ther 1998;12:291-9.

5. Giamberardino MA, Dragani L, Valente R, et al. Effects of prolonged L-carnitine administration on delayed muscle pain and CK release after eccentric effort. Int J Sports Med 1996;17:320-4.

6. Green RE, Levine AM, Gunning MJ. The effect of L-carnitine supplementation on lean body mass in male amateur body builders. J Am Diet Assoc 1997;(suppl):A-72.

7. Murray MT. The many benefits of carnitine. Am J Natural Med 1996;3:6-14 [review].

8. Columbani P, Wenk C, Kunz I, et al. Effect of L-carnitine supplementation on physical performance and energy metabolism of endurance-trained athletes: a double blind crossover field study. Eur J Appl Physiol 1996;73:434-9.

9. Dal Negro R, Pomari G, Zoccatelli O, Turco P. L-carnitine and rehabilitative respiratory physiokinesitherapy: metabolic and ventilatory response in chronic respiratory insufficiency. Int J Clin Pharmacol Ther Toxicol 1986;24:453-6.

10. Dal Negro R, Turco P, Pomari C, De Conti F. Effects of L-carnitine on physical performance in chronic respiratory insufficiency. Int J Clin Pharmacol Ther Toxicol 1988;26:269-72.

11. Beers MH, Berkow R (eds). The Merck Manual of Diagnosis and Therapy, 17th ed. Whitehouse Station, NJ: Merck and Co., Inc, 1999, 881-3.

12. Yesilipek MA, Hazar V, Yegin O. L-Carnitine treatment in beta thalassemia major. Acta Haematol 1998;100:162-3.

13. Dipalma JR. Carnitine deficiency. Am Fam Physician 1988;38:243-51.

14. Kendler BS. Carnitine: an overview of its role in preventive medicine. Prev Med 1986;15:373-90.

15. Tamamogullari N, Silig Y, Icagasioglu S, Atalay A. Carnitine deficiency in diabetes mellitus complications. J Diabetes Complications 1999;13:251-3.

16. Del Favero A. Carnitine and gangliosides. Lancet 1988;2:337 [letter].

17. Kobayashi A, Masumura Y, Yamazaki N. L-carnitine treatment for congestive heart failure-experimental and clinical study. Jpn Circ J 1992;56:86-94.

 

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Dr. Tsang wishes to share his knowledge & Opinion with the public regarding the importance of " Nutritional Supplements ". This is for your information only. Drugs have powerful effects on the body, so please don't abruptly stop taking any prescription medication. Always consult your physician or health care provider before you use any nutritional supplement or switch from drugs to natural health products. 

 

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