1998 Nobel Prize in Medicine was awarded jointly to Robert F Furchgott, Louis J Ignarro and Ferid Murad for their discoveries concerning "nitric oxide as a signaling molecule in the cardiovascular system".

Further research results rapidly confirmed that NO is a signal molecule of key importance for the cardiovascular system. We know today that NO acts as a signal molecule in the nervous system, as a weapon against infections, as a regulator of blood pressure and as a gate keeper of blood flow to different organs.

• When NO is produced by the innermost cell layer of the arteries, the endothelium, it rapidly spreads through the cell membranes to the underlying muscle cells. Their contraction is turned off by NO, resulting in a dilatation of the arteries. In this way, NO controls the blood pressure and its distribution. It also prevents the formation of thrombi.
• When NO is formed in nerve cells, it spreads rapidly in all directions, activating all cells in the vicinity. This can modulate many functions, from behaviour to gastrointestinal motility.
• When NO is produced in white blood cells (such as macrophages), huge quantities are achieved and become toxic to invading bacteria and parasites.

• Heart: In atherosclerosis, the endothelium has a reduced capacity to produce NO. However, NO can be furnished by treatment with nitroglycerin. Large efforts in drug discovery are currently aimed at generating more powerful and selective cardiac drugs based on the new knowledge of NO as a signal molecule.
• Shock: Bacterial infections can lead to sepsis and circulatory shock. In this situation, NO plays a harmful role. White blood cells react to bacterial products by releasing enormous amounts of NO that dilate the blood vessels. The blood pressure drops and the patient may become unconscious. In this situation, inhibitors of NO synthesis may be useful in intensive care treatment.
• Lungs: Intensive care patients can be treated by inhalation of NO gas. This has provided good results and even saved lives. For instance, NO gas has been used to reduce dangerously high blood pressure in the lungs of infants. But the dosage is critical since the gas can be toxic at high concentrations.
• Cancer: White blood cells use NO not only to kill infectious agents such as bacteria, fungi and parasites, but also to defend the host against tumors. Scientists are currently testing whether NO can be used to stop the growth of tumors since this gas can induce programmed cell death, apoptosis.
• Impotence: NO can initiate erection of the penis by dilating the blood vessels to the erectile bodies. A dietary supplement called "ArginMax" based on NO production was released this Spring in California.
• Diagnostic analyses: Inflammatory diseases can be revealed by analysing the production of NO from e.g. lungs and intestines. This is used for diagnosing asthma, colitis, and other diseases.
• NO is important for the olfactory sense and our capacity to recognize different scents. It may even be important for our memory.

Arginine (Amino Acid) is required in the body to synthesize nitric oxide. Nitric oxide enables the arterial system to retain its youthful elasticity, which may alleviate hypertension in some people.  Nitric oxide helps to produce endothelial relaxation factor, which is needed by the arterial system for expansion and contraction with each heart beat. The inability of arteries to expand and contract in the penis and is a major cause of impotence. 

The California based "Daily Wellness Company" developed the ArginMax for men and women sexual wellness based on NO production. ArginMax is the only nutritional supplement for sexual health that has been confirmed by a major clinical study with rigorous control and valuation techniques. A distinguished panel of Scientific Advisory Board oversees product development and clinical trials to ensure product value and efficacy.

Scientific Advisory Board of the "Daily Wellness Company"

• Eugene Bleck, M.D. (Surgical Sciences) Dr. Bleck is Professor and Chairman Emeritus of the Division of Orthopedic Surgery at Stanford University School of Medicine.
• Walter Chien, M.D. (Cardiology) Dr. Chien is clinical Assistant Professor of Medicine at the University of California, San Francisco, and visiting Professor at the Peking Union Medical College of the Chinese Academy of Medical Science
• Anurag K. Das, M.D. (Urology) Dr. Das is Assistant Professor of Surgery and Urology at Albany Medical College and Attending Urologist at Albany Medical Center Hospital.
• Thomas Ito, M.D. (Urology) Dr. Ito is Assistant Professor of Surgery at the University of Hawaii, a member of the Board of Directors for the Pacific Health Care Health Maintenance Organization and Medical Director for the Kidney Stone Center.
• Kaye K. Kawahara, M.D. (Oncology) Dr. Kawahara is an expert in bone marrow and stem cell transplantation and is Director of Bone Marrow Transplantation at the Queen's Medical Center and St. Francis Medical Center in Honolulu.
• Jerome Hahn Kim, M.D. (Infectious Diseases) Dr. Kim is Assistant Professor of Medicine, Microbiology and Immunology at the University of Maryland School of Medicine's Institute of Human Virology.
• Tai Tian Lim, M.D. (Interventional Cardiology) Dr. Tai Tian Lim is a Fellow of the Academy of Medicine of Singapore, Senior Lecturer in the Department of Medicine, Division of Cardiology, at the National University of Singapore.
• Edward Silverblatt, M.D. (Gastroenterology) Dr. Silverblatt is Clinical Professor of Medicine at the Stanford University School of Medicine and former Deputy Dean of the Department of Medicine at Stanford University Hospital.

Safe and side-effect free! (Woman's World, June 29, 1999)

ArginMax contains the amino acid L-Arginine, a naturally occurring substance that is believed to aid the body's production of nitric oxide. The clinical studies revealed that ArginMax does not exhibit side effects such as nausea, vomiting, dizziness, chest pain, change in blood pressure, change in vision or stomach upset.

The net effect is an increase in efficiency of the N.O. pathway and an increase in Nitric Oxide production, which leads to enhanced circulation and arousal.

ArginMax safely enhances the female sexual experience by improving circulation. Sufficient blood flow is critical to female arousal, engorgement and lubrication.

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Dr. Tsang wishes to share his knowledge & Opinion with the public regarding the importance of " Nutritional Supplements ". This is for your information only. He is not in any way try to replace your physician. Drugs have powerful effects on the body, so please don't abruptly stop taking any prescription medication. Always consult your physician or health care provider before you use any nutritional supplement or switch from drugs to natural health products.