Dr. HingHau Tsang's Crusade on Nutrition

 

Newsletter #128 --- Update on stress and Cortisol control

 

Cortisol, the "stress hormone", is produced by the adrenal gland cortex in response to stress.

When exposed to internal or external stress, the brain sends a signal to the adrenal glands to increase cortisol secretion. The body responds by providing a surge in energy, increasing mental alertness, and raising blood pressure, preparing the body for the "fight-or-flight" response.

Cortisol is intricately involved in many physiological functions such as the regulation of healthy blood sugar, maintenance of healthy blood pressure and immune system function, and promotion of the body's natural anti-inflammatory response.

Increased or prolonged exposure to stress can lead to elevated cortisol levels. Elevated cortisol, in turn, can lead to changes in body chemistry, altering the balance of hormones and affecting the systems of the body. Research has shown that maintaining healthy cortisol levels can reduce stress, relieve sleeplessness and fatigue, and optimize immune system and neurological function.

 

Natural approach to elevated cortisol level in addition to Newsletter #102

  1. Keep the adrenal glands well-nourished with crucial nutrients including vitamin B6, pantothenic acid, vitamin C which are often become depleted when continuously making cortisol. Adequate amounts of calcium, magnesium, potassium, manganese, zinc are needed for effective regulation of the cortisol feedback control mechanism. Take Basic Preventive 5 Plus extra vitamin D daily.
  2. Reduce elevated cortisol levels with the followings.

In a recent clinical trial involving 21 healthy volunteers, study subjects took a nutritional supplement, Cortisol Manager, for 45 days. Cortisol Manager combined Ashwagandha, Magnolia, Epimedium, phosphatidylserine and L-theanine. It is formulated to lower cortisol levels and reduce feeling of anxiety. The subjects collected their own Cortisol Manager dietary supplement combines the cortisol-lowering ingredients ashwagandha (Withania somnifera) and phosphatidylserine with the anxiety-relieving components magnolia officinalis and L-theanine. saliva samples at five scheduled intervals throughout the day. The results demonstrated that Cortisol Manager decreased salivary cortisol levels in relation to baseline at all five sampling times throughout the day. The effect began almost immediately and persisted on a consistent basis throughout the entire 45 day duration of the study, averaging between 75% and 83% for the pooled subject data. Participants reported additional benefits associated with cortisol-lowering, including increased feelings of relaxation throughout the day (71%), improved sleep/deeper sleep (71%/64%), and reduced levels of stress (57%). This supplement promotes relaxation and supports a healthy sleep cycle without the use of habit forming ingredients.

Cortisol Manager is a safe and natural formula to increase the ability to fall asleep, stay asleep, while also providing all-day stress reduction. Long-term use supports healthy cortisol levels, which in turn can help reduce stress, relieve ocasional sleeplessness and fatigue, optimize immune system and neurological function.

 

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Reference:

  1. An open label pilot study of the safety and effectiveness of a cortisol-reducing combination in healthy adults. 2006. Unpublished.
  2. Capaldi Ii VF, Handwerger K, Richardson E, Stroud LR. Associations between sleep and cortisol responses to stress in children and adolescents: a pilot study. Behav Sleep Med.2005;3(4):177-92.
  3. Oh MH, Houghton PJ, Whang WK, Cho JH. Screening of Korean herbal medicines used to improve cognitive function for anti-cholinesterase activity. Phytomedicine. 2004 Sep;11(6):544-8.
  4. Hellhammer J. Effects of soy lecithin phosphatidic acid and phosphatidylserine complex (PAS) on the endocrine and psychological responses to mental stress. Stress. 2004 Jun;7(2):119-26.
  5. Compositions and methods of use for extracts of magnoliaceae plants. United States Patent number 6,814,987. November 9, 2004.
  6. Bhattacharya SK. Adaptogenic activity of Withania somnifera: an experimental study using a rat model of chronic stress. Pharmacol Biochem Behav. 2003 Jun;75(3):547-55.
  7. Bhattacharya A. Anti-oxidant effect of Withania somnifera glycowithanolides in chronic footshock stress-induced perturbationsof oxidative free radical scavenging enzymes and lipid peroxidation in rat frontal cortex and striatum. J Ethnopharmacol. 2001 Jan;74(1):1-6.
  8. Benton D. The influence of phosphatidylserine supplementation on mood and heart rate when faced with an acute stressor. Nutr Neurosci. 2001;4(3):169-78.
  9. Prinz PN, Bailey SL, Woods DL. Sleep impairments in healthy seniors: roles of stress, cortisol, and interleukin-1 beta. Chronobiol Int. 2000 May;17(3):391-404.
  10. Kuribara H. The anxiolytic effect of two oriental herbal drugs in Japan attributed to honokiol from magnolia bark. J Pharm Pharmacol. 2000 Nov;52(11):1425-9.
  11. Mishra LC, Singh BB, Dagenais S. Scientific basis for the therapeutic use of withania somnifera (Ashwagandha): a review. Altern Med Rev. 2000;5(4):334-346.
  12. Bhattacharya SK. Anxiolytic-antidepressant activity of Withania somnifera glycowithanolides: an experimental study. Phytomedicine. 2000;7(6):463-9.
  13. Melamed S, Ugarten U, Shirom A, Kahana L, Lerman Y, Froom P. Chronic burnout, somatic arousal and elevated salivary cortisol levels. J Psychosom Res. 1999 Jun;46(6):591-8.
  14. Kuribara H, Stavinoha WB, Maruyama Y. Honokiol, a putative anxiolytic agent extracted from magnolia bark, has no diazepam-like side-effects in mice. J Pharm Pharmacol. 1999 Jan;51(1):97-103.
  15. Juneja LR, Chu DC, Okubo T, Nagato Y, Yokogoshi H. L-theanine - a unique amino acid of green tea and it's relaxation effect in humans. Trends in Food Science & Technology. 1999;10:199-204.
  16. Archana R, Namasiviayam A. Antistressor effect of withania somnifera. J Ethnopharm. 1999;64:91-93.
  17. Lehne RA. Glucocorticoids. In: Pharmacology for Nursing Care, 3rd ed. Philadelphia, Pa: WB Saunders, 1998:616-8.
  18. Ito K. Effect of l-theanine on the release of alpha-brain waves in human volunteers. Nippon Nogeikagaku Kaishi. 1998;72:153-157.
  19. Yokogoshi H, Mochizuki M, Saitoh K. Theanine-induced reduction of brain serotonin concentration in rats. Biosci Biotechnol Biochem. 1998 Apr;62(4):816-7.
  20. Ziauddin M. Studies on the immunomodulatory effects of Ashwagandha. J Ethnopharmacol. 1996;50:69-76.
  21. Monteleone P. Effects of phosphatidylserine on the neuroendocrine response to physical stress in humans. Neuroendocrinology. 1990 Sep;52(3):243-8.

 

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Dr. Tsang wishes to share his knowledge & Opinion with the public regarding the importance of " Nutritional Supplements ". This is for your information only. Drugs have powerful effects on the body, so please don't abruptly stop taking any prescription medication. Always consult your physician or health care provider before you use any nutritional supplement or switch from drugs to natural health products. 

 

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