UBQH is the first true ubiquinol (QH) product that offers the best in CoQ10 therapy

Dr. HingHau Tsang's Crusade on Nutrition

Newsletter #125 --- UBQH, the most active form of CoQ10

CoQ10 (ubiquinone) is commonly prescribed for cardiovascular, neurological, immune support, periodontal health and anti-aging care.

Although CoQ10 is produced by the body and exists in some dietary sources, these levels may be insufficient to meet the body's requirements. Additionally, a deficiency can result from increasing age or increased tissue demands. However, supplementing with CoQ10 may not be enough.

It has been previously demonstrated through research utilizing Vitaline Coenzyme q10 that supplemental coenzyme Q10 raises serum and mitochondrial levels of CoQ10, thereby supporting healthy cellular respiration. Because nearly every cell in the body undergoes the process of cellular respiration, this leads, in turn, to support of diverse health systems, including brain, heart, immune and periodontal health. CoQ10 and its active form, Ubiquinol (QH), are also potent antioxidants. QH has been shown to recharge the antioxidant vitamin E to its active, potent form.

However, in order to benefit the body, the CoQ10 must be converted to its most active form - Ubiquinol (QH) - but not everyone is able to achieve this conversion.

Ubiquinone (Coenzyme Q10, CoQ10) and Ubiquinol (QH) are closely related compounds naturally occurring in the human body. CoQ10 is converted to its active form, Ubiquinol (QH), as a necessary and essential step in the production of cellular energy. Cellular respiration is a multi-step process by which calories from food are converted into cellular energy, and stored in the form of adenosine triphosphate (ATP). This activity involves three major steps: glycolysis, the Krebs cycle, and oxidative phosphorylation. It is during the final step - oxidative phospborylation - that CoQ10 is converted to active QH.

The conversion rate of CoQ10 to QH tends to decline with age, resulting in lower serum of QH. A genetic trait in the human population has also been linked to impaired ability to conduct this conversion. Approximately 30-50% of humans have a genetic make-up that inhibits the conversion of CoQ10 (ubiquinone) to its active and reduced form of QH (ubiquinol), further depleting levels below what is required to support cellular energy and promote overall health.

As we age, the ability to utilize CoQ10 may be reduced by as much as 25% because the decrease of conversiion ratio from CoQ10 to QH (ubiquinol). From the diagram illustrated below, QH (ubiquinol) supplementation maintains QH serum level even as we age. If over 40 years old - consider upgrading to QH - the active form of CoQ10 for maximum benefits.

Healthy human CoQ1O levels are 97% QH and 3% CoQ10. However, some individuals have substantially lower levels of QH - as low as 40% as in individuals with liver problems, Diabetics and kidney diseases demonstrated at the diagram below.

People's age and genetics require the active form of CoQ10 - If you don't feel the benefits of CoQ10, you could be one of the 30-50% of people who can't fully utilize typical CoQ10 supplements. Consider changing to QH - the most active form of CoQ10.

People requiring high doses of CoQ10 as well as people who have problems with CoQ10 conversion will benefit greatly from QH - the most active form of CoQ10.

Introducing UBQH- QH -the most active form of CoQ10

After more than ten years of research, scientist have developed the first true ubiquinol (QH) product in the world. QH is very unstable outside of the body and it readily converts to CoQ10 when exposed to oxygen. There has been no alternative to CoQ10 supplementation until now. Using a patented process to stabilize QH, the most active form of CoQ10 retains its structure and unique properties. UBQH ubiquinol is patented, stable and reduced form of CoQ10, which provides the direct supplementation that mere CoQ10 cannot. UBQH contains this stabilized, active ubiquinol, which has been shown to have greater bioactivity than CoQ10 and up to 8x the absorption of Coq10.

UBQH is designed especially for those individuals whose DNA cannot properly process CoQ10 or those that are experiencing a natural decline in CoQ10 production associated with aging or those requiring higher doses of CoQ10 for neurological health.

UBQH has enhanced bioavailability - 62% higher than CoQ10.

Scientific Research

Studies have shown that supplemental QH have the same health benefits as CoQ10, in a more active form - one step in the conversion process of CoQ10 to QH is eliminated.

Scientific studies of QH have additionally found that it provides support for healthy aging. It increases stamina and energy.

In an evaluation of energy (calculated as time to fatigue) in an animal model, older animals received placebo, CoQ10, and QH in crossover design. Running times were measured in each group. When the animals received QH running times were prolonged 150 fold versus placebo. Increases during the CoQ10 supplementation period did not reach statistical significance.

In an experiment which used an animal model of aging, QH supplementation was associated with healthier aging (as determined by skin, eye, skeletal and general health) in comparison to aging in the both the CoQ10 and control group. The control group in this experiment experienced double the senescence scores in midlife when compared to the QH group, while the CoQ10 supplemented group had senescence scores approximately 1.5 times as high as the QH group. Increased senescence scores are an indication of the signs of aging.

Bioavailability studies in humans are ongoing. The amount of plasma and brain levels CoQ10 increase compared with oral CoQ10 is variable, and based on age and genetics. However, results to date have found that intake of active QH is associated with total serum CoQ10 (ubiquinone plus ubiquinol) levels at least 2 times higher than oxidized CoQ10.

The safety of QH has been extensively studied. Acute toxicity and short term safety studies found no significant adverse effects. Genotoxicity tests, including Ames, chromosome and micronucleus tests, were all negative.

UBQH offers the best in CoQ10 therapy - your will feel the difference.

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Reference:

Yan J, Fujii K, Yao, et al. Reduced coenzyme Q10 supplementation decelerates senescence in SAMP1 mice. Exp Gerontol. 2006 Feb;41 (2):130-40.

Miles MV Morrison JA, Horn PS, et al. LPL and NQO1 genotypes are associated with decreased Coenzyme Q10 redox ratio. lnternational Congress of Clinical Chemistry and American Association for Clinical Chemistry Annual Meeting, July 2005.

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Beyer RE, Sequra-Aguilar J, Di Bernardo S, Cavazzoni M, Fato R, Fiorentini D, Galli Mc, Setti M, Landi L, Lenaz G. The two-electron quinono reductase DT-diaphorase generates and maintains the antioxidant (reduced form of coenzyme Q in membranes. MoI Aspects Med. 1997; 18Suppl:S15-23.

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Dr. Tsang wishes to share his knowledge & Opinion with the public regarding the importance of " Nutritional Supplements ". This is for your information only. Drugs have powerful effects on the body, so please don't abruptly stop taking any prescription medication. Always consult your physician or health care provider before you use any nutritional supplement or switch from drugs to natural health products.

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