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Melatonin Sublingual
This formulation generally delivers faster action than swallowing regular melatonin tablet.
Dosage 3 mg. Size 60 tablet
Direction
Adults take 1 tablet sublingually 1 hour before bedtime or as directed by physician. Taken sublingually means allowing tablet to dissolve under the tongue or with water or juice.
Ingredient
Melatonin (purest pharmaceutical grade) 3 mg
About Melatonin
Melatonin is a hormone produced by the pineal gland, the organ which regulates the body's wake/sleep/wake cycle. The hormone is secreted in a circadian rhythm by enzymes which are activated by darkness and depressed by light. Melatonin nutritionally augments the natural functioning of the pineal gland. Physiologists recognize Melatonin as the hormone that keeps us in sync with the rhythms of the day as well as the season. Through its effect on other hormones, it helps determine when people sleep.
Warning: If you are under medical supervision, suffering from a serious illness, using any tranquilizers, anti-depressants, sedatives or other drugs seek the advice of your health care provider prior to using. Consult your health care provider before using if you have an autoimmune condition, diabetes, endocrine disorder or are a pregnant or lactating woman. May cause daytime drowsiness. Do not take before operating machinery or driving a vehicle. Keep out of reach of children. Store in a cool, dry place, tightly closed.
Scientific Evidence
Sleep Disorder
One double-blind placebo-controlled study enrolled 320 people and followed them for 4 days after plane travel. The participants were divided into four groups and given a daily dose of 5 mg of standard melatonin, 5 mg of slow-release melatonin, 0.5 mg of standard melatonin, or placebo.1 The group that received 5 mg of standard melatonin slept better, took less time to fall asleep, and felt more energetic and awake during the day than the other three groups. According to one review of the literature, melatonin treatment for jet lag is most effective for those who have crossed a significant number of time zones, perhaps eight.2 Melatonin might be particularly helpful for individuals who rely on benzodiazepine drugs to sleep.3 In addition, individuals trying to quit using sleeping pills may find melatonin helpful. A double-blind placebo-controlled study of 34 individuals who regularly used such medications found that melatonin at a dose of 2 mg nightly (controlled-release formulation) could help them discontinue the use of the drugs.4 Note: There can be risks in discontinuing benzodiazepine drugs. Consult your physician for advice.
Cancer
Melatonin has been used with conventional anticancer therapy in more than a dozen clinical studies. Results have been surprisingly good, although this research must be considered preliminary. For example, a double-blind study on 30 people with advanced brain tumors suggested that melatonin might prolong life and also improve the quality of life.5
Participants received standard radiation treatment with or without 20 mg daily of melatonin. After 1 year, 6 of 14 individuals in the melatonin group were still alive, compared with just 1 of 16 from the control group. The melatonin group also had fewer side effects due to the radiation treatment-a notable improvement in their quality of life. Improvements in symptoms and a possible reduction of mortality were also seen in other studies.6,7 Melatonin appears to work by increasing levels of the body's own tumor-fighting proteins, known as cytokines.8References
1. Suhner A, Schlagenhauf P, Johnson R, et al. Comparative study to determine the optimal melatonin dosage form for the alleviation of jet lag. Chronobiol Int. 1998;15:655-666.
2. Arendt J, Skene DJ, Middleton B, et al. Efficacy of melatonin in jet lag, shift work and blindness. J Biol Rhythms. 1997;12:604-617.
3. Garfinkel D, Laudon M, Zisapel N. Improvement of sleep quality by controlled-release melatonin in benzodiazepine-treated elderly insomniacs. Arch Gerontol Geriatr. 1997;24:223-231.
4. Garfinkel D, Zisapel N, Wainstein J, et al. Facilitation of benzodiazepine discontinuation by melatonin: a new clinical approach. Arch Intern Med. 1999;159:2456-2460.
5. Lissoni P, Meregalli S, Nosetto L, et al. Increased survival time in brain glioblastomas by a radioneuroendocrine strategy with radiotherapy plus melatonin compared to radiotherapy alone. Oncology. 1996;53:43-46.
6. Lissoni P, Paolorossi F, Ardizzoia A, et al. A randomized study of chemotherapy with cisplatin plus etoposide versus chemoendocrine therapy with cisplatin, etoposide and the pineal hormone melatonin as a first-line treatment of advanced non-small cell lung cancer patients in a poor clinical state. J Pineal Res. 1997;23:15-19.
7. Lissoni P, Tancini G, Barni S, et al. Treatment of cancer chemotherapy-induced toxicity with the pineal hormone melatonin. Support Care Cancer. 1997;5:126-129.
8. Neri B, de Leonardis V, Gemelli MT, et al. Melatonin as biological response modifier in cancer patients. Anticancer Res. 1998;18:1329-1332.
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This is a statement of nutritional support. This statement has not been evaluated by the FDA. This product is not intended to medically diagnose, treat, cure, or prevent any disease. Always consult your health care provider before using any supplement.