Tsang Nutrition
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Cogni-flex
Nutritional support for healthy mental function
Dosage
100 mcg Size 60 capsulesDirection
Adults take 1 -2 capsule with a meal daily or as directed by physician. Recommend to take at least 8 weeks to see clinical improvement
Ingredient
Each Capsule Contains:
Huperzine A 100 mcg.
Ginkgo biloba 20 mg. (standardized to 24% ginkgoflavonglycosides
and 6% terpene lactones)
Phosphatidylserine 10 mg.
Acetyl-L-Carnitine 10 mg.
Other ingredients: Cellulose, gelatin, vegetable stearate and silica
About Cogni-flex
The four nutrients in Cogni-flex support the structure and function of cognitive processes in several ways. They support neurotransmitter metabolism, enhance vascular circulation to the brain, and help maintain structure and function of nerve cell membranes.
Huperzine A is a 100% natural - from an extract of Chinese club moss (Huperzia serrata), and is one of the most exciting new products for memory and cognition, particularly for older men and women.
Huperzine A supports memory and concentration and healthy brain functioning by preserving levels of the important neurotransmitter, acetylcholine. With BioPerine, a natural, standard extract of black pepper, to help the body absorb the active nutrient more efficiently.
Huperzine A may significantly improve memory and mental function -- with none of the negative side effects of commonly prescribed prescription drugs. HupA has been used in Chinese medicine for centuries to treat inflammation and fever. HupA works in a similar fashion to the two most commonly prescribed drugs for Alzheimer's disease, tacrine (Cognex) and donepezil (Aricept). All three inhibit the breakdown of acetylcholine. While all three have been shown to enhance memory, boost acetylcholine and protect brain cells from toxins, HupA has none of the significant side effects of the prescription drugs, which can cause nausea, vomiting, excess sweating and salivation, and liver damage. HupA also has a longer duration than both of these drugs. Several studies have shown that HupA improves brain function in patients with dementia. HupA seems to have additional properties that may help it to slow the progression of Alzheimer's. One study showed that it can slow the formation of a harmful kind of plaque, a buildup of protein deposits in the brain. Other studies indicate that it can protect brain cells from glutamate, a neurotransmitter that becomes toxic when it is secreted in large amounts. Some research also indicates that Huperzine A helps to block the process of inflammation that occurs as Alzheimer's disease progresses. The recommended dose of Huperzine A is 100-200 mcg per day in divided doses.
Ginkgo Biloba extract is also reported to inhibit the tendency of red blood cells to stick together (clumping), thereby enhancing the functional fluidity of the blood. Improving the functional circulation to the brain and other parts of the body allows for better oxygen and glucose uptake, with subsequent enhancement of memory and mental functions.
Phosphatidylserine: This phospholipid, found in high concentrations in the nervous system, helps maintain functional fluidity of nerve cell membranes, thus providing for optimal transport of nutrients and other compounds across the cell membrane. It is also used in the repair and regeneration of nerve cells. Phosphatidylserine also appears to help the body counterbalance excessive release of adrenocorticotropic hormone (ACTH), adrenaline, and cortisol which are released in response to stress.
Acetyl-L-carnitine: This acetylated high energy ester of the amino acid L-carnitine contributes its acetyl group to the production of acetylcholine, the primary neurotransmitter for memory and thought. The enzyme that makes acetylcholine from acetyt groups and choline is choline acetyl transferase. The activity of this important enzyme has a tendency to decline with age, causing low acetylcholine levels which in turn are thought to contribute to the impairment of brain function that is associated with aging. Research has also found that acetyl-L-carnitine is active in optimizing the functioning of cerebral blood flow, as well as of nerve cell membranes.
Warning:
Internal use not advised during pregnancy or nursing.
Keep out of the reach of children.
Cautions:
Huperzine A is generally non-toxic. No significant side effects reported. Mild, transient headaches may occur during the first 2-3 days of taking Ginkgo Biloha in people with previously insufficient cerebral blood tlow, indicating the activity of this herb.
Ginkgo Biloba may potentiate the action of anticoagulants and central nervous system drugs. Some cases of dizziness and the potential for nausea or excessive salivation are possible. It is probably better to use intermittently. Before stopping Huperzine A completely, it is safer to taper dose gradually over a week.Scientific Evidence
All clinical trials of huperzine to date were performed in China.
A double-blind placebo-controlled study evaluated 103 people with Alzheimer's disease who received either huperzine A or placebo twice daily for 8 weeks.
18 About 60% of the treated participants showed improvements in memory, thinking, and behavioral functions compared to 36% of the placebo-treated group, and the difference was significant.Benefits were also seen in an earlier double-blind trial using injected huperzine in 160 individuals with dementia or other memory disorders
.19Huperzine is also reportedly helpful for improving memory in healthy individuals. A double-blind trial of 34 matching pairs of junior middle school students reported improvements in memory in the treated group.20
References
1. Zhang RW, Tang XC, Han YY, et al. Drug evaluation of huperzine A in the treatment of senile memory disorders [in Chinese, English abstract]. Chung Kuo Yao Li Hsueh Pao. 1991;12:250-252.
2. Cheng DH, Tang XC. Comparative studies of huperzine A, E2020, and tacrine on behavior and cholinesterase activities. Pharmacol Biochem Behav. 1998;60:377-386.
3. Cheng DH, Ren H, Tang XC. Huperzine A, a novel promising acetylcholinesterase inhibitor. Neuroreport. 1996;8:97-101.
4. Xiong ZQ, Tang XC. Effect of huperzine A, a novel acetylcholinesterase inhibitor, on radial maze performance in rats. Pharmacol Biochem Behav. 1995;51:415-419.
5. Zhi QX, Yi FH, XI CT. Huperzine A ameliorates the spatial working memory impairments induced by AF64A. Neuroreport. 1995;6:2221-2224.
6. Zhu XD, Giacobini E. Second generation cholinesterase inhibitors: effect of (L)-huperzine-A on cortical biogenic amines. J Neurosci Res. 1995;41:828-835.
7. Zhang GB, Wang MY, Zheng JQ, et al. Facilitation of cholinergic transmission by huperzine A in toad paravertebral ganglia in vitro [in Chinese, English abstract]. Chung Kuo Yao Li Hsueh Pao. 1994;15:158-161.
8. Laganiere S, Corey J, Tang XC, et al. Acute and chronic studies with the anticholinesterase Huperzine A: effect on central nervous system cholinergic parameters. Neuropharmacology. 1991;30:763-768.
9. Tang XC, De Sarno P, Sugaya K, et al. Effect of huperzine A, a new cholinesterase inhibitor, on the central cholinergic system of the rat. J Neurosci Res. 1989;24:276-285.
10. Tang XC, Han YF, Chen XP, et al. Effects of huperzine A on learning and the retrieval process of discrimination performance in rats [in Chinese]. Chung Kuo Yao Li Hsueh Pao. 1986;7:507-511.
11. Guan LC, Chen SS, Lu WH, et al. Effects of huperzine A on electroencephalography power spectrum in rabbits [in Chinese, English abstract]. Chung Kuo Yao Li Hsueh Pao. 1989;10:496-500.
12. Lu WH, Shou J, Tang XC. Improving effect of huperzine A on discrimination performance in aged rats and adult rats with experimental cognitive impairment [in Chinese]. Chung Kuo Yao Li Hsueh Pao. 1988;9: 11-15.
13. Wang YE, Feng J, Lu WH. Pharmacokinetics of huperzine A in rats and mice [in Chinese]. Chung Kuo Yao Li Hsueh Pao. 1988;9:193-196.
14. Wang YE, Yue DX, Tang XC. Anti-cholinesterase activity of huperzine A [in Chinese]. Chung Kuo Yao Li Hsueh Pao. 1986;7:110-113.
15. Zhu XD, Tang XC. Improvement of impaired memory in mice by huperzine A and huperzine B [in Chinese]. Chung Kuo Yao Li Hsueh Pao. 1988;9:492-497.
16. Zhu XD, Tang XC. Facilitatory effects of huperzine A and B on learning and memory of spatial discrimination in mice [in Chinese]. Yao Hsueh Hsueh Pao. 1987;22:812-817.
17. Yan XF, Lu WH, Lou WJ, et al. Effects of huperzine A and B on skeletal muscle and the electroencephalogram [in Chinese]. Chung Kuo Yao Li Hsueh Pao. 1987;8:117-123.
18. Xu SS, Goa ZX, Weng Z, et al. Efficacy of tablet huperzine-A on memory, cognition, and behavior in Alzheimer's disease. Chung Kuo Yao Li Hsueh Pao. 1995;16:391-395.
19. Zhang RW, Tang XC, Han YY, et al. Drug evaluation of huperzine A in the treatment of senile memory disorders [in Chinese; English abstract]. Chung Kuo Yao Li Hsueh Pao. 1991;12:250-252.
20. Sun QQ, Xu SS, Pan JL, et al. Huperzine-A capsules enhance memory and learning performance in 34 pairs of matched adolescent students [abstract]. Chung Kuo Yao Li Hsueh Pao. 1999;20:601-603.
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This is a statement of nutritional support. This statement has not been evaluated by the FDA. This product is not intended to medically diagnose, treat, cure, or prevent any disease. Always consult your health care provider before using any supplement.