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Grape Seed Extract, Enzymatic, division of ITI
Size
90 capsulesDosage:
100 mgDirection:
Adults take 1 capsule 3 times daily.
Ingredient:
Grape (Vitis vinifera) Seed Extract
standardized to contain 95% polyphenols, including procyanidolic oligomers (PCOs) 100 mg
Other Ingredients:
Cellulose, vegetable capsule (modified cellulose), modified cellulose gum, and magnesium stearate.
This product contains natural ingredients; color variations are normal.
Free Of Sugar, salt, yeast, wheat, gluten, corn, soy, dairy products, artificial coloring, artificial flavoring, preservatives, and ingredients of animal origin.
Warnings
: If pregnant, nursing, or taking prescription drugs, consult your healthcare practitioner prior to use.About Grape Seed Extract 
Grape seeds are a potent source of proanthocyanidins, or pycnogenols containing naturally occurring proanthocyanidins, natural powerful Antioxidant. Proanthocyanidins, a highly specialized group of bioflavonoids, have been extensively studied since the late 1960's for their powerful vascular wall strengthening properties and free radical scavenging activity. Proanthocyanidins (OPCs or PCOs) are one of the most potent free radical scavengers known, possessing an antioxidant effect up to 50 times more potent then vitamin E and up to 20 times more powerful then vitamin C. Proanthocyanidins also have an affinity for cell membranes, providing nutritional support to reduce capillary permeability and fragility. The powerful proanthocyanidin compound is most abundant and available from the bark of the maritime pine and in grape seeds, or pips. Grape seed is rich in the catechin form of proanthocyanidins, plant flavonoids. Catechins help protect against oxidative damage to cholesterol, soothe mucous membranes like those in the digestive system, and inhibit certain enzymes which may lead to the growth of undesirable bacteria in the intestines.
No side effect known if taken as directed.
Scientific Studies
Varicose Veins and Hemorroids
A double-blind placebo-controlled study of 71 subjects with Venous Insufficiency (Varicose Veins) found that grape seed OPCs, taken at a dose of 100 mg 3 times daily, significantly improved major symptoms, including heaviness, swelling, and leg discomfort.1
A double-blind study of 50 people with varicose veins of the legs found that doses of 150 mg per day of OPCs were more effective in reducing symptoms and signs than another natural treatment: the bioflavonoid diosmin, widely used in Europe for this condition.2 Hemorrhoid is actually a special kind of varicose vein. On the basis of their evidence for varicose veins, OPCs are often recommended as a treatment for hemorrhoids as well.
Edema After Surgery or Injury
A double-blind placebo-controlled study of 63 post-operative breast cancer patients found that 600 mg of OPCs daily for 6 months reduced edema, pain, and peculiar sensations known as paresthesias.3
Also, in a double-blind placebo-controlled study of 32 "face-lift" patients who were followed for 10 days, edema disappeared much faster in the treated group.4Night vision
One interesting 6-week controlled (but not blinded) study evaluated the ability of grape seed OPCs to improve night vision in normal subjects.5,6
In this trial of 100 healthy volunteers, those who received 200 mg per day of OPCs showed improvements in night vision and glare recovery as compared to untreated subjects.Atherosclerosis
Although there are no reliable human studies, animal evidence suggests that OPCs can slow or reverse atherosclerosis
.7,8,9 This suggests (but definitely does not prove) that OPCs might be helpful for preventing heart disease.References
1. Thebaut JF, Thebaut P, Vin F. Study of Endotelon ® in functional manifestations of peripheral venous insufficiency [translated from French]. Gaz Med. 1985;92:96-100.
2. Delacroix P Double-blind study of Endotelon ® in chronic venous insufficiency [translated from French]. La Revue de Medecine. Aug/Sept.1981;no.27-28:1793-1802.
3. Pecking A, Desprez-Curely JP, Megret G. Oligomeric grape flavanols (Endotelon ®) in the treatment of secondary upper limb lymphedemas [translated from French]. [source unknown] 1989 ;69-73.
4. Baruch J. Effect of Endotelon in postoperative edema. Results of a double-blind study versus placebo in 32 female patients [translated from French]. Ann Chir Plast Esthet. 1984;29:393-395.
5. Corbe C, Boissin JP, Siou A. Light vision and chorioretinal circulation. Study of the effect of procyanidolic oligomers [translated from French]. J Fr Ophtalmol. 1988;11:453-460.
6. Boissin JP, Corbe C, Siou A. Chorioretinal circulation and dazzling: use of procyanidol oligomers [in French; English abstract]. Bull Soc Ophtamol Fr. 1988;88:173-174, 177-179.
7. Schwitters B, Masquelier J. OPC in Practice: Bioflavanols and their Applications. Rome, Italy:Alfa Omega; 1993.
8. Wegrowski J, Robert AM, Moczar M. The effect of procyanidolic oligomers on the composition of normal and hypercholesterolemic rabbit aortas. Biochem Pharmacol. 1984;33:3491-3497.
9. Gendre PM, Laparra J, Barraud E. Protective effect of procyanidolic oligomers on experimental lathyrism in rats [in French; English abstract]. Ann Pharm Fr. 1985;43:61-71.
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This is a statement of nutritional support. This statement has not been evaluated by the FDA. This product is not intended to medically diagnose, treat, cure, or prevent any disease. Always consult your health care provider before using any supplement.