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 Tsang Nutrition

Home of Natural Remedies & Nutritional Information

Gluco-Mend

A special combination of nutrients and herbal extracts, this formula helps to maintain proper blood sugar levels.

Size 90 cap

Direction

To start, adults take 1 capsules three times a day before each meal.

Titrate dosage upwards as directed by physician. Blood glucose monitoring is essential. Maximal daily dosage 12 capsules.

Ingredients per 3 vegetarian capsules:

Alpha Lipoic Acid 100 mg. Chromium GTF 200 mcg.

Vanadium (Vanadyl Sulfate) 2.5 mg

Gymnema sylvestre (standardized) 200 mg.

Bitter Melon Extract 200 mg. Fenugreek Seed Extract 150 mg.

Garcinia cambogia Extract 835 mg. Supplying 500 mg. of HCA

SIDE EFFECTS

Gluco-Mend is generally well-tolerated and do not cause side effects. However, blood sugar monitoring is necessary. Adjustment in diabetic medication may be needed under the supervision of your health care provider.

Warning

Not recommended during pregnancy and nursing.

Keep out of reach of children.

About Gluco-Mend

(Please read Newsletter #17 Maintain healthy blood sugar)

Gluco-Mend helps to maintain proper blood sugar levels by the combined actions of the following nutrients and herbal extracts.

Alpha-lipoic acid is a fat- and water-soluble, sulfur-containing coenzyme. It functions in the body much like a B-vitamin, since it is involved in energy production. As part of several multi-enzyme complexes located in the mitochondria, alpha-lipoic acid is essential for metabolizing carbohydrates, proteins, and fats, and for the conversion of their energy into ATP. A related metabolic function of alpha-lipoic acid is its role in blood glucose disposal. This important coenzyme appears to be necessary for the normal transport of blood glucose into the cell.

Gyrnnerna sylvestre is an Ayurvedic botanical that assists in the regeneration and repair of pancreatic beta cells. Gymnema is also suspected of reduing intestinal glucose absorption.

At least three different groups of constituents in bitter melon (Momordica charantia) have been reported to have hypoglycemic (blood sugar lowering) or other actions of potential benefit in diabetes mellitus. These include a mixture of steroidal saponins known as charantin, insulin-like peptides, and alkaloids.

Research shows that hydroxycitric acid (HCA) helps maintain a healthy balance of hepatic lipogenesis and gluconeogenesis, thus preventing excessive conversion of glucose from carbohydrate into body fat. It is found in Garcinia camhogia, a tropical fruit.

Chromium is an integral component of the glucose tolerance factor (GTF), a naturally occurring compound of chromium, nicotinic acid, and amino acids that is essential for proper glucose metabolism. Adequate chromium nutrition is essential for the formation of GTF and subsequent control of blood glucose levels.

Fenugreek seeds contain steroidal saponins (diosgenin, yamogenin, tigogenin, and neotigogenin) and mucilaginous fiber. The steroidal saponins lower cholesterol by inhibiting cholesterol absorption and synthesis , while the fiber helps lower blood sugar levels.

Vanadyl sulfate may improve glucose control in people with type 2 (non-insulin-dependent) diabetes mellitus.

Clinical Studies of Alpha lipoic acid (ALA)

Preliminary evidence suggests that Alpha lipoic acid improves other aspects of diabetes as well, including circulation in small blood vessels, metabolism of sugar and protein, and the body's response to insulin.2-6

Several open studies show benefits for oral Alpha lipoic acid in reducing symptoms of diabetic peripheral neuropathy .7-11

The DEKAN (Deutsche Kardiale Autonome Neuropathie) study followed 73 people with diabetes who had symptoms caused by nerve damage affecting the heart. Treatment with 800 mg daily of oral ALA showed statistically significant improvement.7

References of Alpha lipoic acid (ALA)

1. Book "Alpha Lipoic Acid , Nature's Ultimate Antioxidant" written By Allan Sosin, MD

2. Jacob S, Henriksen EJ, Schiemann AL, et al. Enhancement of glucose disposal in patients with type 2 diabetes by alpha-lipoic acid. Arzneimittelforschung. 1995;45:872-874.

3. Kawabata T, Packer L. Alpha-lipoate can protect against glycation of serum albumin, but not low density lipoprotein. Biochem Biophys Res Commun. 1994;203:99-104.

4. Nagamatsu M, Nickander KK, Schmelzer JD, et al. Lipoic acid improves nerve blood flow, reduces oxidative stress, and improves distal nerve conduction in experimental diabetic neuropathy. Diabetes Care. 1995;18:1160-1167.

5. Suzuki YJ, Tsuchiya M, Packer L. Lipoate prevents glucose-induced protein modifications. Free Radic Res Commun. 1992;17:211-217.

6. Jacob S, Ruus P, Hermann R, et al. Oral administration of RAC-alpha-lipoic acid modulates insulin sensitivity in patients with type-2 diabetes mellitus: a placebo-controlled pilot trial. Free Radic Biol Med. 1999;27:309-314.

7. Ziegler D, Gries FA. Alpha-lipoic acid in the treatment of diabetic peripheral and cardiac autonomic neuropathy. Diabetes. 1997;46(suppl 2):S62-S66.

8. Kahler W, Kuklinski B, Ruhlmann C, et al. Diabetes mellitus-a free radical-associated disease. Results of adjuvant antioxidant supplementation [in German; English abstract]. Z Gesamte Inn Med. 1993;48:223-232.

9. Ziegler D, Hanefeld M, Ruhnau KJ, et al. Treatment of symptomatic diabetic peripheral neuropathy with the anti-oxidant alpha-lipoic acid. A 3-week multicentre randomized controlled trial (ALADIN Study). Diabetologia. 1995;38:1425-1433.

10. Packer L, Witt EH, Tritschler HJ. Alpha-lipoic acid as a biological antioxidant. Free Radic Biol Med. 1995;19:227-250.

11. Ruhnau KJ, Meissnert HP, Finn JR, et al. Effects of 3-week oral treatment with the antioxidant thioctic acid (alpha-lipoic acid) in symptomatic diabetic polyneuropathy. Diabet Med. 1999;16:1040-1043.

Clinical Studies references of Chromium, Bitter Melon (Momordica charantia), Gyrnnerna sylvestre, Vanadium and Fenugreek

1.Anderson, RA. Chromium, glucose intolerance, and diabetes. J Am Coll Nutr 1998:17:548-55.

2.Raman A, Lao C. Anti-diabetic properties and phytochemistry of Momordica charantia (Curcurbitaceae). Phytomed Res 1996;2:349-62.

3. Shanmugasundaram ER, Rajeswari G Raskaran K, et al. L Use of Gyrnnerna sylvestre leaf extract in the control of blood glucose in insulin-dependent diabetes meltitus. I Ethnopharmacol 1990: 30: 2S 1-94.

4. Boden G, Chen X, Ruiz J, et al. Effects of vanadyl sulfate on carbohydrate and lipid metabolism in patients with non-insulin-dependent diabetes mellitus. Metabolism 1996;45:1130-5.

5. Bordia A, Verma SK, Srivastava KC. Effect of ginger (Zingiber officinale Rosc) and fenugreek (Trigonella foenumgraecum L) on blood lipids, blood sugar, and platelet aggregation in patients with coronary artery disease. Prostagland Leukotrienes Essential Fatty Acids 1997;56:379-84.

6. Sharma RD, Raghuram TC, Rao NS. Effect of fenugreek seeds on blood glucose and serum lipids in type I diabetes. Eur J Clin Nutr 1990;44:301-6.

7. Madar Z, Abel R, Samish S, Arad J. Glucose-lowering effect of fenugreek in non-insulin dependent diabetics. Eur J Clin Nutr 1988;42:51-4.

8. Raghuram TC, Sharma RD, Sivakumar B, Sahay BK. Effect of fenugreek seeds on intravenous glucose disposition in non-insulin dependent diabetic patients. Phytother Res 1994;8:83-6.

9. Prasanna M. Hypolipidemic effect of fenugreek: A clinical study. Indian J Phramcol 2000;32:34-6.

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Disclaimer

This is a statement of nutritional support. This statement has not been evaluated by the FDA. This product is not intended to medically diagnose, treat, cure, or prevent any disease. Always consult your health care provider before using any supplement.

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