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5-HTP from Integrative Therapeutics Inc. 50mg 60 ultracaps $18 Add To Cart
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5 HTP from Douglas Labs 50mg 100 cap $35
Add To Cart(Peak-X is the substance causing eosinophilia-myalgia syndrome)
Dose:
50mg Size:100 capsulesDirection
One to two capsules per day.between meals or as directed by a physician. One must ensure an adequate intake of vitamin B6. which is necessary for the conversion of 5 HTP to serotonin.
Ingredients-
Certified free of "Peak X"Each capsule contains:
L-5-Hydroxytryptophan (5 HTP) 50mg
Other ingredients: Cellulose, gelatin, water.
Contains no: yeast, corn, wheat, soy, sugar, sweeteners, artificial flavors, colors or preservatives.
Side effects
Used as directed, the safety of 5-HTP is well documented.
Few side effects have been reported including headache, nasal congestion, nausea, drowsiness and constipation.
Warning
Not for use during pregnancy and nursing.
5-HTP may potentiate the effect of alcohol and certain drugs such as antidepressant (including MAO inhibitors, SSRI) and weight loss medications. Always consult with their physician before taking.
Keep out of reach of children.
About 5 HTP
5-HTP (L-5-Hydroxytryptophan) is a brain serotonin precursor.
A natural and safe alternative to tryptophan. 5-HTP is used by the body to synthesize serotonin, a neurohormone needed for melatonin production, appetite regulation, and mood regulation. 5-HTP is a natural product extracted from the seeds of the Griffonia plant, unlike tryptophan which is produced synthetically or through bacterial fermentation. 5-HTP crosses into the brain more readily than tryptophan as it is able to cross the blood-brain barrier without competition for uptake. 5-HTP is significantly more effective than tryptophan. Finally, research studies have shown 5-HTP to be safe at levels as high as 900 mg. As a result, 5-HTP is a safe and effective means of increasing brain serotonin levels.
Clinical studies
Fibromyalgia
In a Double-blind controlled trial, 5-HTP (300 mg per day) was shown to be effective in reducing many symptoms of fibromyalgia, including pain, morning stiffness, sleep disturbances, and anxiety.1,2,3,6
Insomnia
For insomnia, a single 100-mg nighttime dose of 5-HTP was sufficient to improve the duration and depth of sleep in one placebo-controlled trial.5,10
Depression
For depression, 300 mg per day is often effective, though much of the research used 5-HTP in combination with drugs or was uncontrolled.7, 8, 9
Migraine headaches
The cause of migraine headaches is related to abnormal serotonin function in blood vessels,4 and 5-HTP may help correct this abnormality. For migraine headaches, amounts ranging from 400-600 mg per day have been shown to be effective at reducing the frequency and severity of attacks in most clinical trials.11, 12, 13, 14, 15
Weight loss and obesity
5-HTP reduces appetite by balancing levels of serotonin in the brain. Appetite reduction and weight loss (averaging 11 pounds in 12 weeks) has occurred with amounts of 600-900 mg daily.16, 17 In another clinical trial, 750 mg per day has been shown to be effective at decreasing carbohydrate and fat intake, and promoting weight loss.18
References
1. Russell IJ, Michalek JE, Vipraio GA, et al. Platelet 3H-imipramine uptake receptor density and serum serotonin levels in patients with fibromyalgia/fibrositis syndrome. J Rheumatol 1992;19:90-4.
2. Yunus MB, Dailey JW, Aldag JC, et al. Platelet 3H-imiprimine uptake receptor density and serum serotonin levels in patients with fibromyalgia/fibrositis syndrome. J Rheumatol 1992;19:104-9.
3. Wolfe F, Russell IJ, Vipraio G, et al. Serotonin levels, pain threshold, and fibromyalgia symptoms in the general population. J Rheumatol 1997;24:555-9.
4. Kimball RW, Friedman AP, Vallejo E. Effect of serotonin in migraine patients. Neurology 1960;10:107-11.
5. Schneider-Helmert D, Spinweber CL. Evaluation of L-tryptophan for treatment of insomnia: A review. Psychopharmacology (Berlin) 1986;89(1):1-7.
6. Caruso I, Sarzi Puttini P, Cazzola M, Azzolini V. Double-blind study of 5-hydroxytryptophan versus placebo in the treatment of primary fibromyalgia syndrome. J Int Med Res 1990;18:201-9.
7. Byerley WF, Judd LL, Reimherr FW, Grosser BI. 5-hydroxytryptophan: A review of its antidepressant efficacy and adverse effects . J Clin Psychopharmacol 1987;7:127-37 [review].
8. Zmilacher K, Battegay R, Gastpar M. L-5-hydroxytryptophan alone and in combination with a peripheral decarboxylase inhibitor in the treatment of depression. Neuropsychobiology 1988;20:28-35.
9. Poldinger W, Calanchini B, Schwarz W. A functional-dimensional approach to depression: serotonin deficiency as a target syndrome in a comparison of 5-hydroxytryptophan and fluvoxamine. Psychopathology 1991;24(2):53-81.
10. Soulairac A, Lambinet H. Etudes cliniques de líaction du precurseur de la serotonine le L-5-hydroxy-tryptophane, sur les troubles du sommeil. Schweiz Bundschau Med (PRAXIS) 1998;77(34a):19-23 [in French].
11. De Benedittis G, Massei R. 5-HT precursors in migraine prophylaxis: a double-blind cross-over study with L-5-hydroxytryptophan versus placebo. Clin J Pain 1986;3:123-9.
12. Titus F, Davalos A, Alom J, Codina A. 5-hydroxytryptophan versus methysergide in the prophylaxis of migraine. Eur Neurol 1986;25:327-9.
13. Maissen CP, Ludin HP. Comparison of the effect of 5-hydroxytryptophan and propranolol in the interval treatment of migraine. Schweizerische Medizinische Wochenschrift /Journal Suisse de Medecine 1991;121:1585-90 [in German].
14. Mathew NT. 5-hydroxytryptophan in the prophylaxis of migraine. Headache 1978;18:111-3.
15. De Giorgis G, Miletto R, Iannuccelli M, et al. Headache in association with sleep disorders in children: a psychodiagnostic evaluation and controlled clinical study ñ L-5-HTP versus placebo. Drugs Exptl Clin Res 1987;13(7):425-33.
16. Ceci F, Cangiano C, Cairella M, et al. The effects of oral 5-hydroxytryptophan administration on feeding behavior in obese adult female subjects.J Neural Transm 1989;76(2):109-17.
17. Cangiano C, Ceci F, Cascino A, et al. Eating behavior and adherence to dietary prescriptions in obese adult subjects treated with 5-hydroxytryptophan. Am J Clin Nutr 1992;56:863-7.
18. Cangiano C, Laviano A, Del Ben M, et al. Effects of oral 5-hydroxy-tryptophan on energy intake and macronutrient selection in non-insulin dependent diabetic patients. Int J Obes Relat Metab Disord 1998;22:648-54.
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This is a statement of nutritional support. This statement has not been evaluated by the FDA. This product is not intended to medically diagnose, treat, cure, or prevent any disease. Always consult your health care provider before using any supplement.